Article 26 – Wireless Magnetoelectric Stimulation Platform Orchestrating Multicellular Coupling in Complex Neurovascularized Tissue Regeneration

Abstract:

Bone regeneration is a well-orchestrated biological process involving coordinate efforts of multiple cells, cytokines, and signals, among which nerves play a dominant role in regulating osteogenesis. Draw inspiration from the inherent electroactive features of bone and nerve, bioelectric implant providing wireless delivery of electrical stimulation (ES), is an emerging alternative to conventional invasive electrode-based therapy. Herein, we develop a lead-free magnetoelectric (ME) core–shell MnFe₂O₄@Ba_0.85Ca_0.15Zr_0.1Ti_0.9O₃ (MFO@BCZT) nanoheterostructure-integrated biodegradable 3D-printed hydrogel implant providing high-performance wireless ES for neurovascularized bone regeneration. Under low-intensity magnetic field stimulation (20 mT, 50 Hz), the strain generated by the magnetostriction of MFO core is directly transmitted into BCZT piezoelectric shell to generate electrical signals. Thus, 3D-printed ME implants activate multiple neurogenesis- and osteogenesis-related signals including calcium ion-mediated CaMKII/CREB and CaMKKβ/AMPK/Nrf2 pathway, as well as other pro-regenerative pathways including PI3K-AKT and TGF-β signaling. The implants recreate electrophysiological microenvironments of bone defect in vivo, thereby inducing early neuroangiogenesis and recruiting endogenous stem cells, resulting in 3.1-fold and 4.6-fold increase in innervation and bone formation, respectively. Beyond bone repair, this magnetically driven electrical stimulation strategy establishes a ME-multicellular coupling platform for minimally invasive complex tissue regenerative therapies. Furthermore, the stimuli-responsive 3D-printed ME hydrogel implant establishes a versatile foundation for multifunctional wireless bioelectronic interfaces, allowing a single system to integrate therapeutic and neuroelectronic functions with potential applications in treating traumatic brain injury and neurological disorders, as well as in next-generation brain–machine interfaces.

Title: Wireless Magnetoelectric Stimulation Platform Orchestrating Multicellular Coupling in Complex Neurovascularized Tissue Regeneration

Authors: Hongjian Zhang; Polina V. Chernozem; Roman A. Surmenev; Maria A. Surmeneva; Dmitry V. Wagner; Evgeny Yu. Gerasimov; Abdulkarim A. Amirov; Andrei L. Kholkin; Zhiguang Huan; Yufang Zhu; Roman V. Chernozem ; Chengtie Wu

Reference: ACS Nano, 20 (30): 21294–21315, 2026

DOI: https://doi.org/10.1021/acsnano.6c06339

Article 31 – Hysteresis phenomena in Cd2P2S6 layered crystals

2026-09-29

Abstract: The results of the study of the temperature dependence of the dielectric permittivity of Cd2P2S6 crystals are presented. It is shown that in the temperature range 80–420 K there are three regions in which hysteresis phenomena are observed. At high temperatures (T > 320 K) there is an activation change of the dielectric

Article 30 – The influence of electric field on the anisotropic dispersion of the flexocoupling induced phonons and ferrons in van der Waals ferrielectrics

2026-09-29

Abstract: As it has been shown recently, the influence of the flexoelectric coupling (shortly “flexocoupling”) on the fluctuations of electric polarization and elastic strains can lead to the principal changes of the dispersion law of soft optical and acoustic phonons (shortly “flexophonons”) and ferrons (shortly “flexoferrons”) in van der Waals

Article 29 – The impact of morphological structure and flexo-chemical strains on the electric transport mechanisms in molybdenum-disulfide-oxide nanoflakes

2026-09-29

Abstract: Electric conduction mechanisms in pressed powder samples consisting of molybdenum-disulfide-oxide (MoSxOy) nanoflakes depending on their content and structure have been investigated. The MoSxOy nanoflakes were synthesized in the temperature range of 130 °C–180 °C by reaction of (NH4)6Mo7O24 with thiourea in aqueous solution followed by aerial oxidation. The chemical

Article 28 – Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core–Shell Nanotransducers under Remotely Applied Magnetic Fields

2026-09-29

Abstract: Magnetoelectric nanoparticles (MENPs), combining a magnetostrictive core with a piezoelectric shell, offer a promising route for remote-controlled biomedical applications by converting external magnetic fields into electric cues. However, the clinical translation of these materials remains limited due to the toxicity of high-performance piezoelectric materials, which typically contain lead. Previously,

Article 27 – Colossal dielectric response of H⁡f𝑥⁡Z⁢r1−𝑥⁢O2 nanoparticles

2026-09-29

Abstract: We observed a colossal dielectric response of small (5–10 nm) oxygen-deficient H⁡f𝑥⁡Z⁢r1−𝑥⁢O2 nanoparticles (𝑥=1–0.4), prepared by solid-state organonitrate synthesis. The effective dielectric permittivity of the pressed H⁡f𝑥⁡Z⁢r1−𝑥⁢O2 nanopowders has a pronounced maximum at 38–88∘⁢C, the shape of which can be fitted by the Curie-Weiss type dependence modified for the